UNICO tells the incredible story of a young unicorn who, after enraging the evil goddess Venus, is banished from the heavens and forgets all he once was. Saved from oblivion by the kindhearted West Wind, Unico continues to help others, before having to escape Venus again and begin a new adventure.
In this first manga, Unico awakes in a mysterious land and is befriended by a resourceful watch cat, Chloe, who feels protective of the young unicorn. When they find themselves near a small village in the forest, they take refuge with a kindly, but helpless, old woman. To take care of her, Chloe begs Unico to turn her into a human girl, but that act of kindness has unforeseen consequences: Unico's love has awakened Venus and her minion, Byron, who want to destroy them both!